LEVELS OF CERTAIN HORMONES AND RECEPTORS IN TUMOR AND PERITUMORAL AREA IN BALB/C NUDE FEMALE MICE WITH MULTIPLE PRIMARY MALIGNANT PROCESS DEVELOPING ON THE BACKGROUND OF PRIMARY IMMUNODEFICIENCY

Primary immunodeficiency is one of the reasons for development primary multiple malignant tumors.
 The aim study to examine levels certain hormones and their receptors in tissue peritumoral area B16/F10 melanoma Lewis lung carcinoma (LLC) case isolated combined subcutaneous growth female mice with T-cell immunodeficiency.
 Materials Methods. BALB/c Nude were divided into groups: intact group; 2 control groups (Group 1 inoculation, Group LLC inoculation); main group (animals LLC+B16/F10 inoculation). ELISA method was used determine free testosterone (Tf.), estrone (E1), prolactin (PRL), estrogen (REα REβ), androgen (RA) progesterone (RP4) (Cassabio, China). Statistical processing obtained results carried out on a personal computer using STATISTICA 10.0, parametric Student's test nonparametric Wilcoxon-Mann-Whitney test.
 Results. In group, life expectancy reduced due by 1.8 times decrease 2.3 times. animals LLC+B16/F10, compared those an only tumor variant, level tumors decreased, but increased. Melanoma accompanied increase some sex steroid tissue, its area, skin not affected process. A females all studied both area.
 Conclusions. probably associated high unaffected skin, being source melanocytes, cells from which this develops.